High tin intake reduces copper status in rats through inhibition of copper absorption.
نویسندگان
چکیده
The mechanism underlying the reduced Cu status in rats fed on a high-Sn diet was investigated. Male rats aged 4 weeks were fed ad lib. on purified diets containing either 1 or 100 mg Sn/kg and demineralized water for a period of 4 weeks. The high-Sn diet had no effect on feed intake, body-weight gain or weight of liver and kidney but significantly reduced Cu concentrations in plasma, liver and kidney. Biliary Cu excretion was decreased significantly in rats fed on the high-Sn diet. Apparent Cu absorption (Cu intake-faecal Cu) was not affected by the high-Sn diet, but the estimate of true Cu absorption (Cu intake-(faecal Cu-biliary Cu)) was significantly reduced. We conclude that high Sn intake reduces Cu status in rats through inhibition of Cu absorption. The decreased biliary Cu excretion observed on the high-Sn diet is a result of the reduced Cu absorption.
منابع مشابه
Increasing intakes of iron reduce status, absorption and biliary excretion of copper in rats.
High intakes of Fe may impair Cu status, but the underlying mechanism is not known. Male rats, aged 7 weeks, were given purified diets adequate in Cu (8 mg Cu/kg) and containing either 7, 40 or 389 mg Fe/kg. After 6 weeks the concentrations of Fe in liver and spleen were positively related with dietary Fe level and those of Cu were negatively related with dietary Fe level. Increasing Fe intakes...
متن کاملIncreasing intakes of iron reduce status, absorption and biliary excretion of copper in rats
High intakes of Fe may impair Cu status, but the underlying mechanism is not known. Male rats, aged 7 weeks, were given purified diets adequate in Cu (8 mg Cu/kg) and containing either 7, 40 or 389 mg Fe/kg. After 6 weeks the concentrations of Fe in liver and spleen were positively related with dietary Fe level and those of Cu were negatively related with dietary Fe level. Increasing Fe intakes...
متن کاملInfluence of hypertension and dietary copper on indexes of copper status in rats.
The Dahl salt-sensitive rat was used to investigate the effect of hypertension on indexes of copper status and to determine the extent to which dietary manipulation of copper attenuated, or exacerbated, the rate of sodium chloride-induced hypertension. Weanling salt-sensitive rats were fed, in a 2 x 3 factorial design, one of six diets that contained one of three levels of copper (2.0 microgram...
متن کاملHigh Dietary Fructose Compared With Corn Starch Does Not Heighten Changes in Copper Absorption, Retention, or Status Indicators in Men Fed Low Dietary Copper
In experimental animals, high dietary fructose exacerbates signs of copper deficiency in rats. Thus, an experiment was performed to determine whether high dietary fructose affected copper metabolism and copper status indicators in healthy men who were fed low dietary copper. Six men aged 27 to 37 years completed a metabolic unit study divided into four 7-week dietary periods with a randomized, ...
متن کاملEffect of iron supplements on serum copper status in pregnant women in Islamshahr
Introduction: Iron deficiency anemia is recognized as the most prevalent nutrient deficiency in the world and iron supplements, which are prescribed daily in pregnant women for prevention of this anemia, may have unfavorable effects on copper absorption. The purpose of this study was to determine the effects of iron supplementation on serum copper status of pregnant women. Materials and Methods...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The British journal of nutrition
دوره 73 6 شماره
صفحات -
تاریخ انتشار 1995